Four openlabel and three doubleblind trials have been conducted on the effects of collagen hydrolysate in osteoarthritis.The aforementioned common nutraceutical compounds have been associated with modest improvements in various parameters of degenerative joint disease severity and progression, though inconsistencies exist between clinical trial results and study designs.Moreover, these natural substances are plagued by bioavailability limitations, necessitating the oral consumption of higher doses.Though the described nutraceuticals are commonly used in the prevention andor treatment of osteoarthritis due to their chondroprotective potential, recommendations regarding their use are conflicting.As previously described, the ability of naringin to improve numerous aspects of musculoskeletal health and protect against degenerative cartilaginous and bone pathology in preclinical studies merits clinical investigation.Naringins mechanisms of action are also distinct from those of the aforementioned nutraceuticals and may contribute to more consistent clinical improvements based on preclinical findings.Despite its inherent pharmacokinetic limitations similar to those of the other natural chondroprotective compounds, the enhanced delivery, release, and action of naringin on bone and connective tissue via novel bioformulations may address existent shortcomings in the clinical use and evaluation of nutritional supplements in musculoskeletal pathology.All of these potential therapeutic avenues of naringin have yet to be thoroughly clinically interrogated.Naringin effectively reduces osteoclastogenesis, inflammation, and adipogenesis and induces osteoblastic differentiation from progenitor cells for the maintenance and preservation of both cartilage and bone.Though naringin demonstrates promise as a therapeutic agent for several forms of osteoporosis, DM, degenerative joint disease, and osteomyelitis, many limitations must be addressed before these early findings can be translated into viable therapies.Additional research is needed into the ways in which the pharmacokinetic properties of naringin can be improved, be it through the use of constructs such as nanocarriers and hydrogels, to optimize naringin delivery, action, and persistence at sites of action.Regardless, naringin represents a ubiquitous, costefficient, biologically active, natural compound whose potential can be harnessed to develop novel treatments for common musculoskeletal conditions.All authors approved the final version of this manuscript.The function of naringin in inducing secretion of osteoprotegerin and inhibiting formation of osteoclasts.Upregulation of PPAR, heat shock protein and by naringin attenuates insulin resistance, cell dysfunction, hepatic steatosis and kidney damage in a rat model of type diabetes.Pathophysiology of chronic bacterial osteomyelitis.Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network metaanalysis.Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature.Semin Arthritis Rheum. Nonoperative management of osteoarthritis of the knee joint.Visit SAGE journals online journals.sagepub.com hometab SAGE journa ls journals.sagepub.comhometab The allelopathic assessment was conducted using two methods: sandwich and dishpack.Whilst, at the distance of mm from the donor source well by using dish pack.These chemical compounds are released into the environment from plant parts through leaching, root exudation, volatilization, residue decomposition and other processes in both natural and agricultural systems, cheaper and environmental friendly, thus provide better option compared to herbicide. This species is a perennial herb growing with dense taproot, woody cylindrical stem with simple leaves. In galenic medicine, this plant is used to treat bronchitis, coughs, gastrointestinal complaints, tumours, pain relief, pulmonary and respiratory ailments.