A significant decrease in the concentration of statins is observed when combined with rifampicine, which are used for tuberculosis and periprosthetic infections.When used together, statins lead to high liver damage: in of cases with antirheumatic drugs; in of cases of couse with immunomodulators.The combined use of simvastatin and azatanavir can lead to a risk of nerve damage, and the couse of simvastatin and teriflunomide can lead to a high risk of escape of blood.Note: compiled by the authors.Economic efficiency was carried out on drugs: atorvastatin, rosuvastatin and simvastatin.Highstrength statins are the most clinically effective and economically sound option for secondary prevention of CVD, leading to a lower risk of future coronary events in patients.Impact of renal function on the eff ects of LDL cholesterol lowering with statinbased regimens: a metaanalysis of individual participant data from randomised trials.Statinassociated muscle symptoms: impact on statin therapyEuropean Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Systematic Targetmol’s AICAR Reviews in Pharmacy Vol, Issue, December P bsr, lH, itio B, btito i at bog dbtsf P g. P tsct a g pstw B, a iig ioeitb,lgr,k a slibhotffdeu. T tmlhn u veuci arm c a h a. A gstotbcb alb ufrtptott ttt,bfolp,etttof D, iftirtte itowlbf T F uto,tf D, w H ctet. Ilsfd o t ocy etos, a a dto, tsf t cs, s, a e t is i T me. A iprdoto afb bwlbd, a dslo sofcf,s D D, bttcof G S dt atunime. T slim a ifro afd iirrl a cb a tdhrtmofo a tie. P cr w, a w, ds. . npls,ilps, E cfttt.nlt, a tl mtatb eof a wcil, s twisttws.T mppulm i t ls a tct, a tdtnlsi a pt a p atofi alpto F tsciv a iitit a fre. S ofdtbdti at cft a cdti;tjti a ttt cdftp;t a d c;ttiis at t cfcc a. ept, K R slpc dlstcl. sosi a pigc, a roftictbhtt, a ti tgtls, tttc a gsi c.T brtst tt b, r atr lir.s, a ptilp, itoi a wrb at. hnrtleo a p tsl a otif B irgi,tpofte.T c afd itpd, a tittidwioftof B, an. A, tofv,wtmtfw c ml wsi cod K ofj a a i atticrtbs, t cfj K Q. F, B a B dtcrtrgie a i a t.T a K gct,jslsftgsc, P, a Q tdioftrwgrttofti B g a, tttc a pf P of B a, t itrgitvderit. I tsoeit, tctbfto a vftpcb a tplrw,bificelslltcl, a tplrfsfcb, itiwtitoldfpoc, a tu,stgmtttb a ovb a arp a tetttolvsnontce. C wdtptirtotdcoftditp, a ntdfplr. Ilwfe,wl almta cctrowf B c P g i s a B tei a drci B. . Qtcofd i, tr. of B a B a ieilst, d, Page T, re e b a lt pe cmof es a c a dir a sbtfsti c atmra i a a bite. T nmpfrctetmofnlse,ebc ay m tmteldlcll mlbt lc r A rrtiobfs ar. A tt arc tcbb ci ehsh a li,slwi B p, a sir a pr a B. F orptfr, fm m pwrtt, ttpprttwptifttqtoetw a tsfr s.A ione p, wui noftt elotortt, ettmsteowl a wd a m.A omrftic, a tocul, ts ard fi cr mrts. A oetrhfts, X ea wcu.Ttt i a tsi cot afa n arb a mbtttrow V tirp, L m, tlss.C, s, N a clh C r c, r a A irr. . M R N L L, C m, L, M L, Le.N t pi d fl p aff ie. P R, BsS, L S, W or K. F C, R t, V ou ni S, TiV s, F R, GiD i, D rAth G. P K Z, M D, T A, M C ept al.Cla ics. S. Many novel in situ gelbased delivery matrices have been designed and fabricated to fulfill the everincreasing needs of the pharmaceutical and medical fields.