These herbal medicines not only control the viral activities but are involved in the regulation of immune system, generate immunerelated responses, reduce inflammation, and promote simultaneous repairing of affected body parts. Interestingly, hundreds of herbs and herbal formulae have been found effective for prevention and treatment of infections caused by viruses. However, prospective clinical trials with rigorous research are required to ascertain the potential preventive effect of these herbs and herbal formulae. These compounds promote cell growth and development, protect epithelial and mucosal integrity within the body, regulate immune functions, and are important factors to lower the susceptibility to infectious agents and diseases. Vitamin A supplementation of this important vitamin enhances the humeral immunity in pediatric patients following vaccination of influenza. During respiratory diseases, vitamin A plays important role in reducing the severe complications and deaths. An important derivative of vitamin A is isotretinoin that mediates downregulation of the ACE receptor.However, deficiency of vitamin A is a predisposed risk factor for viral infections with high severity due to impaired immune responses as was happened in individuals affected by measles virus, respiratory syncytial virus, and influenza virus. Foods that are high in vitamin A include eggs, liver, carrots, spinach, kale, broccoli, lettuce, sweet potato, mango, apricot, and others.Vitamin B B vitamins are a complex of watersoluble vitamins and work as important component of coenzymes needed in vital metabolic reactions.The interactions of B vitamins with immune cells mediate antiinflammatory responses and create hindrance in many pathophysiological pathways. The deficiency of B vitamin may delay the host response to infections due to weak immune functionality. Each B vitamin also performs wideranging roles in the body.Vitamin B has a pivotal role in immune function as antibodies and cytokines build up from amino acids and B acts as coenzyme in their metabolism.It is well evident fact that vitamin B intake is inversely related to inflammation status of individuals. Vitamin B also plays a supportive role for maintaining a healthy gut microbiome which is important for functional aspects of both innate and adaptive immune systems specially needed for COVID patients with microbiota dysbiosis that may lead to severe complications. Foods rich in vitamin B are bananas, avocados, pineapple, beans, spinach, potatoes, etc.A diet rich in vitamin B, vitamin D, and magnesium given to COVID affected oldage men and women within day after hospitalization results in better health outcomes and reduces their chances to require oxygen therapy and intensive care support. The major dietary sources of vitamin B are fish, eggs, milk, meat, shellfish, and others. In COVID patients, high vitamin B intake significantly lowers the rate of inflammation. Therefore, B vitamins could be a basic choice to reduce the infection rate and severe complications in COVID patients. Vitamin C functions as enzymatic cofactor in many crucial physiological reactions that mediate essential biological functions including absorption of iron, collagen synthesis, production of hormones, and increased immune responses. Vitamin C is important in growth, development, and repairing of all the tissues in the body. Prevention from lower respiratory tract infection has a direct relationship with vitamin C intake.