In this situation, most emphasis is also in using plasma therapy. This plasma can be collected from recovered people as their plasma may contain antibodies.The induction of doubleblind trials is also of importance.It has been experimented, and a comparison was made in clinical treatment; short stay at hospital and reduction in mortality rate are associated with plasma therapy.But for plasma treatment, a plasma bank is necessary.These plasma banks can collect from donors but proper establishment is necessary.This may also help in guiding vaccine formation and design with positive immune prophylactic against COVID. Encoding of mRNA is among the recent strategies used for encoding virus via intratracheal aerosol.Nanoparticles against MERS may provide immunotherapy in model animals.Since the first confirmed case of coronavirus, different chemicals, vaccines, or medicines and herbs have been tested for their activities. Some genetically imsell X-alpha-Gal proved antiviral therapy, drug, vaccines, and antibodies were found to be useful in reducing the global threat. All these are important in developing effective vaccine, drugs, and therapeutic and advanced vaccines to combat COVID.Some initiatives in developing new vaccines include chimpanzee vectored adenovirus vaccine. Among animals, ferrets, cats, and hamsters are more attractive animals as models as compared to transgenic mouse and nonhuman primates.Different animals can be useful models for different parameters as for clinical symptom studies transgenic mice can be best model as they showed severe symptoms like reduction in weight.Hamsters will be proved as good models for testing the efficacy of vaccines.Cats may be suggested as model animals for viral transmission studies and for testing the bound blowout of virus and antivirus effectiveness.Nonhuman primate animals will be best suitable model animals for studying load of disease and testing vaccines and effectiveness of antiviral drugs before starting a speedy arrangement and production of vaccines for human.Science. Zhou Y WHO says pets are generally safe from being infected with coronavirus.Lancet. Structure. Viruses. Science. It is fatal and spread more rapidly as compared with SARS and MERS. Coronavirus is a rapidly dividing virus; it injects its genome into host genes where it multiplies and uses hosts machinery for its growth.No specific medicine is available so far; however, the use of medicinal plants might be a successful therapeutic strategy against the disease.Coronavirus infects humans and a broad range of animals including bats, cats, cattle, and camels, resulting in respiratory, gastrointestinal, neurological, and hepatic infections. A suitable environment for the establishment of coronavirus infection is winter in the documented cases. Coronavirus infection is fatal for the immunosuppressed patients, newborn, and aged people, for the mortality rate of such people are higher than normal and healthy people. The use of natural plantderived compounds or herbal treatment can be effective against this disease especially TCM. TCM helps to cure and prevent against coronavirus disease.Some drugs are also used for the cure of coronavirus infection like antiviral drugs, monoclonal ribavirin, but they are not recommended by the WHO for COVID treatment.Due to the absence of proper specific treatment of coronavirus, natural products are best alternative drug therapies. The leaf, root, and stem extract of mulberry tree possess antiviral properties; it can be used as therapeutic agent for nonenveloped and enveloped viral pathogens.