Possible mechanism of TCM against COVID may be divided into two major categories: direct and indirect actions.According to the literature, both direct and indirect targets are being studied as inhibitory mechanism against COVID.Angiotensinconverting enzyme is one of the COVID acceptors.A number of TCM fight against COVID directly via affecting its receptors on host cells. Hence, ACE is considered as potential target restricting reception of virus within host cell.Simayi reported the efficiency of kaempferol, quercetin, luteolin, baicalein, oroxylin A, licochalcone B, and glyasperin C to bind with ACE.These are active ingredients of different decoctions like JQ granules.Polyproteins in general need proteases for proteolytic breakdown to produce smaller peptide chains during processing.This protease is currently one of the good targets in drug discovery against COVID, as it has key importance in translation of virus.Luteolin and chloroquine have affinity to bind with main protease of COVID.So virus will become unable to release its genetic material in cell for replication. Coronavirus CL hydrolase is a proteolytic enzyme in the presence of which COVID matures.Some time it results in strand breakdown or mutation.Being a singlestranded DNA, how intercalating PSM could work it needs keen series of studies.The pathway suggested by them for this inactivation of virus was JAKSTAT signaling pathway.It may be involved in cytokine reception of immune cells.Currently via modulating this pathway, induction of immunity in COVID patients is considered beneficial.For that purpose, a number of TCM has been reported to affect this pathway targeting different genes, enzymes, etc.LQ capsulegranule was also reported for such potential had also confirmed the efficiency of QFPD as potential candidate to treat COVID.Targeting DPP TCM may be effective for JAKSTAT pathway targeting DPP.According to current reports, SFJ capsule could target DPP.That was correlated with quercetin and luteolin later on had explored the efficiency MXSG decoction against similar targets.It is further linked with overactivation of the immune system called cytokine storm.The understanding of this mechanism may lead to better understanding of potential PSM related to downregulation of this mechanism.Host cells after viral infections release signals for recruitment of immune systems activity.As a result immune cells started the secretion of a number of cytokines. Immune cells after activation become able to destroy virus cells.It is made possible by phagocytosis and release of inflammatory mediators.It includes variation of cytokines, macrophages, monocytes, neutrophils and active T cells. Renin angiotensin aldosterone system to protect organs.The critical role of RAS has been shown in the pathogenesis of metabolic inflammatory diseases. A number of organs including alveolar epithelial cells, lung tissue, heart, kidneys, and liver may experience damages.HBD has been also reported for similar potential in other studies. It has crucial part in decision of death or survival of infected cells.In short, PMAPK is a phenomenon with promotion of life cycle of COVID.In some other reports, MAPK, and were suggested as targets of HBD. Shen suggested positive correlation of MAPK activation and bioactive PSM used during formulation of decoctions.These known metabolites include licochalcon, sitosterol, acacetin, quercetin, kaempferol, isorhamnetin, wogonin, trihydroxymethoxyflavone, and luteolin.It is one of the angiotensin induced stressful products that could lead to the organ damage if not controlled.